Sources of variation in studies of the early bactericidal activity of antituberculosis drugs
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چکیده
منابع مشابه
Sources of variation in studies of the early bactericidal activity of antituberculosis drugs.
The early bactericidal activity (EBA) of antituberculosis drugs can be measured as the daily fall in cfu counts of Mycobacterium tuberculosis in sputum, usually during the first 2 days of treatment. In studies of low potency drugs, it is necessary to compare the treated group of patients with a group who receives no chemotherapy (Nil group). Over the past 10 years, five Nil groups of between fi...
متن کاملThe early bactericidal activity of antituberculosis drugs.
Early bactericidal activity studies measure the ability of antituberculosis treatments to reduce the burden of Mycobacterium tuberculosis in sputum specimens collected overnight from smear-positive pulmonary tuberculosis patients during the first 14 days of therapy. This confirms the efficacy of novel agents or drug combinations in human patients, allows comparison of different drug dosages and...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2001
ISSN: 1460-2091
DOI: 10.1093/jac/47.2.177